Yes, you can avoid MySQL Error Code 1451 by designing your database relationships with clear dependency rules and ensuring consistent data handling. One simple approach is to use ON DELETE CASCADE or ON UPDATE CASCADE when defining foreign keys, so MySQL automatically updates or removes related child records. This prevents conflicts when modifying parent rows. Another way is to always check for dependent records before deleting a parent entry, ensuring no active child references remain. Regularly cleaning orphaned data and validating data integrity also reduces the chances of triggering the error. By planning foreign key behavior carefully and maintaining clean relational data, you can prevent Error 1451 from interrupting delete or update operations.